Graphdiyne　(GDY),　a　novel　two-dimensional　(2D)　carbon　allotrope　featuring　sp-　and　sp2-hybridized　carbon,　boasts　high　electron　mobility　and　an　intrinsic　direct　band　gap,　making　it　a　promising　candidate　for　spin-based　semiconductor　device　applications.　However,　its　inherent　nonmagnetism　limits　its　potential　in　this　area.　In　this　study,　we　demonstrate　that　dual-doping　GDY　with　fluorine　(F)　and　hydroxyl　(OH)　groups　can　induce　room-temperature　(RT)　ferromagnetism,　the　intensity　of　which　can　be　modulated　by　adjusting　the　levels　of　F　and　OH　dual-doping.　Our　experimental　results　and　theoretical　analyses　reveal　several　key　findings:　(i)　both　dopants　preferentially　adsorb　onto　the　chain　structure　of　GDY,　leading　to　local　magnetic　moments;　(ii)　OH　groups　deter　clustering　of　F　adatoms,　thus　enhancing　magnetic-inducing　efficiency;　and　(iii)　these　magnetic　moments　are　coupled　through　superexchange　interactions　between　magnetic　1,2,3-trimethylbenzene　motifs.　This　carefully　devised　strategy　not　only　facilitates　the　realization　of　RT　ferromagnetic　GDY　but　also　paves　the　way　for　the　development　of　GDY-based　spintronic　devices.　This　advancement　could　potentially　broaden　the　scope　of　applications　for　this　unique　2D　material.　©　2023　American　Chemical　Society.