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author:

Li, Shuyu (Li, Shuyu.) [1] | Zhang, Nan (Zhang, Nan.) [2] | Zhang, Hao (Zhang, Hao.) [3] | Yang, Zhifang (Yang, Zhifang.) [4] | Cheng, Quan (Cheng, Quan.) [5] | Wei, Kang (Wei, Kang.) [6] | Zhou, Meng (Zhou, Meng.) [7] | Huang, Chenshen (Huang, Chenshen.) [8]

Indexed by:

Scopus SCIE

Abstract:

Recent advances in cancer research have highlighted the pivotal role of tertiary lymphoid structures (TLSs) in modulating immune responses, particularly in breast cancer (BRCA). Here, we performed an integrated analysis of bulk transcriptome data from over 6000 BRCA samples using biological network-based computational strategies and machine learning (ML) methods, and identified LGALS2 as a key marker within TLSs. Single-cell sequencing and spatial transcriptomics uncover the role of LGALS2 in TLS-associated dendritic cells (DCs) stimulation and reveal the complexity of the tumor microenvironment (TME) at both the macro and micro levels. Elevated LGALS2 expression correlates with prolonged survival, which is associated with a robust immune response marked by diverse immune cell infiltration and active anti-tumor pathways leading to a 'hot' tumor microenvironment. The colocalization of LGALS2 with TLS-associated DCs and its role in immune activation in BRCA were confirmed by hematoxylin-eosin (HE), immunohistochemistry (IHC), and in vivo validation analyses. The identification of LGALS2 as a key factor in BRCA not only highlights its therapeutic potential in novel TLS-directed immunotherapy but also opens new avenues in patient stratification and treatment selection, ultimately improving clinical management.

Keyword:

Breast cancer immunotherapy Dendritic cell activation LGALS2 Tertiary lymphoid structures Tumor microenvironment

Community:

  • [ 1 ] [Li, Shuyu]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Thyroid & Breast Surg, Wuhan, Peoples R China
  • [ 2 ] [Yang, Zhifang]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Thyroid & Breast Surg, Wuhan, Peoples R China
  • [ 3 ] [Zhang, Nan]Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Wuhan, Peoples R China
  • [ 4 ] [Zhang, Hao]Chongqing Med Univ, Affiliated Hosp 2, Dept Neurosurg, Chongqing, Peoples R China
  • [ 5 ] [Cheng, Quan]Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha 410008, Hunan, Peoples R China
  • [ 6 ] [Cheng, Quan]Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China
  • [ 7 ] [Wei, Kang]Wuhan Univ, Zhongnan Hosp, Dept Plast Surg, Wuhan 430071, Hubei, Peoples R China
  • [ 8 ] [Zhou, Meng]Wenzhou Med Univ, Sch Biomed Engn, Wenzhou 325027, Zhejiang, Peoples R China
  • [ 9 ] [Huang, Chenshen]Fuzhou Univ, Fujian Prov Hosp, Dept Gastrointestinal Surg, Affiliated Prov Hosp, Fuzhou 350001, Fujian, Peoples R China

Reprint 's Address:

  • [Cheng, Quan]Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha 410008, Hunan, Peoples R China;;[Cheng, Quan]Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China;;[Wei, Kang]Wuhan Univ, Zhongnan Hosp, Dept Plast Surg, Wuhan 430071, Hubei, Peoples R China;;[Zhou, Meng]Wenzhou Med Univ, Sch Biomed Engn, Wenzhou 325027, Zhejiang, Peoples R China;;[Huang, Chenshen]Fuzhou Univ, Fujian Prov Hosp, Dept Gastrointestinal Surg, Affiliated Prov Hosp, Fuzhou 350001, Fujian, Peoples R China;;

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Source :

MOLECULAR CANCER

Year: 2024

Issue: 1

Volume: 23

2 7 . 7 0 0

JCR@2023

CAS Journal Grade:1

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 2

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