The　vast　majority　of　research　on　PbTe　thermoelectrics　has　focused　merely　on　advancing　medium-temperature　power　generator,　often　neglecting　near-room-temperature　thermoelectric　properties,　thus　constraining　its　potential　applications　at　low　temperatures.　Here,　we　realize　the　prominent　improvement　of　the　ratio　of　weighted　mobility　and　lattice　thermal　conductivity　in　n-type　PbTe　thermoelectrics　by　manipulating　the　configurational　entropy　of　the　material.　The　severe　lattice　distortion　induced　by　entropy　increase　causes　a　remarkable　strain　field,　which　powerfully　scatters　phonon　and　significantly　lowers　the　lattice　thermal　conductivity.　Simultaneously,　entropy　engineering　effectively　elevates　the　solubility　limit　of　S　in　PbTe,　which　accelerates　the　flattening　of　the　conduction　band,　leading　to　a　larger　Seebeck　coefficient.　As　a　result,　we　obtain　an　impressive　near-room-temperature　zT　in　the　entropy-driven　stabilized　n-type　PbTe.　Based　on　this,　we　further　fabricated　a　seven-pair　thermoelectric　module　by　integrating　commercial　p-type　Bi2Te3,　achieving　a　exceptional　cooling　temperature　difference　of　36.8　K　at　300　K,　and　a　maximum　conversion　efficiency　of　3.2　%　when　the　hot-side　temperature　is　540　K.　Our　present　finding　demonstrates　promising　thermoelectric　applications　for　PbTe-based　materials　near　room　temperature.　©　2025　Elsevier　B.V.