Reversible-deactivation　radical　polymerization　(RDRP　(RDRP)　regulated　by　single-molecule　alkoxyamine　features　a　simple　process,　produces　polymers　with　light　color　and　minimal　odor,　and　is　free　of　metal　ion　impurities.　However,　the　design　and　synthesis　of　alkoxyamines　capable　of　regulating　the　polymerization　of　methacrylate　monomers　remains　a　challenging　task.　In　this　paper,　an　innovative　type　of　alkoxyamine{3-[(2-cyanopropan-2-yl)oxy](isopropyl)amino}-　2,2-dimethyl-3-phenylpropanenitrile(CPDMN)　was　synthesized　via　Schiff　base　reduction,　potassium　persulfate　complex　oxidation　and　radical　coupling,　and　then　the　controlled　polymerization　behavior　of　methyl　methacrylate　(MMA　(MMA)　mediated　by　CPDMN　was　investigated.　The　experimental　results　demonstrate　that　the　monomer　conversion　rate　increases　linearly　with　polymerization　time,　while　the　polymer　molecular　weight　grows　with　prolonged　reaction　duration.　Gel　permeation　chromatography　traces　exhibit　symmetrical　peaks　without　significant　tailing,　indicating　characteristic　features　of　controlled/living　radical　polymerization.　Subsequent　re-initiation　experiments　using　poly　(methyl　methacrylate)　macroinitiator(PMMA-ONR)　with　MMA,　styrene(St),　and　ethyl　methacrylate(EMA)　further　confirm　the　effective　retention　of　alkoxyamine　end-groups　in　the　resulting　polymers.　Finally,　the　regulation　performance　of　CPDMN　on　MMA　in　the　presence　of　oxygen　was　investigated,　achieving　a　monomer　conversion　rate　of　91.2%　and　a　PMMA　molecular　weight　distribution　of　less　than　1.5,　which　demonstrates　that　CPDMN　can　control　the　polymerization　of　MMA　with　oxygen　tolerance.　The　as-synthesized　CPDMN　extends　the　range　of　monomers　applicable　to　nitroxide-mediated　polymerization(NMP),　demonstrating　promising　potential　for　the　synthesis　of　functional　polymeric　materials.