Two　flurorinated　isomeric　polymeric　semiconductors　(P1　and　P2)　containing　benzo[c][1,2,5]thiadiazole　units　have　been　newly　designed　and　synthesized.　Basic　physicochemical　properties,　surface　morphology　and　crystallinity　features　have　been　investigated.　Both　polymers　show　typical　p-type　charge　transport　characteristics.　P1　displays　better　average　hole　mobility　of　＇10(-2)　cm(2)　V-1　s(-1)　with　high　on/off　ratio　of　similar　to　10(6)　and　low　threshold　voltage　of　-2.4.　Both　polymers　exhibit　good　hole　transport　stability　in　ambient　condition　based　on　the　result　of　continuously　monitoring　unencapsulated　device　performances　for　110　days.　The　results　demonstrate　the　isomeric　effect　on　optoelectronic　properties　of　new　flurorinated　polymers,　which　are　promising　semiconductors　for　air-stable　unencapsulated　organic　field-effect　transistor　application.