Directional　and　high-efficiency　charge　transport　to　the　target　active　sites　of　photocatalyst　is　central　to　boost　the　solar　energy　conversion　but　is　retarded　by　the　sluggish　charge　transfer　kinetics　and　deficiency　of　active　sites.　Here,　we　report　the　elaborate　design　of　cascade　unidirectional　charge　transfer　channel　over　spatially　multilayered　CdS@CdTe@MoS2　dual　core-shell　ternary　heterostructures　by　partial　transformation　of　CdS　to　CdTe　interim　layer　followed　by　seamless　encapsulation　with　an　ultrathin　MoS2　layer.　The　suitable　energy-level　alignment　and　unique　coaxial　multilayered　assembly　mode　among　the　building　blocks　accelerate　the　interfacial　charge　separation　and　transport,　endowing　the　CdS@CdTe@MoS2　heterostructures　with　conspicuously　enhanced　visible-light-driven　photocatalytic　hydrogen　generation　performances　along　with　good　photostability.　The　integrated　roles　of　ultrathin　CdTe　intermediate　layer　in　passivating　the　defect　sites　of　CdS　NWs　framework,　mediating　the　unidirectional　charge　transfer　cascade　and　prolonging　the　charge　lifetime,　were　ascertained.　Besides,　the　crucial　role　of　the　outermost　MoS2　layer　as　the　metal-free　cocatalyst　in　enriching　the　surface　active　sites　for　hydrogen　evolution　was　also　determined.　Our　work　would　provide　new　alternatives　for　finely　tuning　the　charge　flow　toward　promising　solar-to-hydrogen　conversion　efficiency.