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Abstract:
SALL4 and OCT4, along with other pluripotency-associated transcription factors, play critical roles in maintaining embryonic stem cell pluripotency and self-renewal. Ku80 is a component of the protein complex called DNA-dependent protein kinase, which mainly involved in DNA double-strand break repair. In this study, we show evidence that Ku80 physically interacted with SALL4. The interaction competitively disrupts the SALL4-OCT4 complex and result in OCT4 lysosomal degradation. Finally, Ku80 inhibits self-renewal and metastasis of hepatocellular carcinoma cells through breaking the SALL4-OCT4 interactions and down-regulating the expression of OCT4. Our study reveal novel function of Ku80 in sternness maintaining of cancer stern cells via its interaction with SALL4 and highlight the double-sidedness of Ku80 as an anti-cancer target.
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INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
ISSN: 1357-2725
Year: 2020
Volume: 118
5 . 0 8 5
JCR@2020
3 . 4 0 0
JCR@2023
ESI Discipline: BIOLOGY & BIOCHEMISTRY;
ESI HC Threshold:156
JCR Journal Grade:2
CAS Journal Grade:3
Cited Count:
WoS CC Cited Count: 3
SCOPUS Cited Count:
ESI Highly Cited Papers on the List: 0 Unfold All
WanFang Cited Count:
Chinese Cited Count:
30 Days PV: 0
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