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author:

Zhao, Bixing (Zhao, Bixing.) [1] | Zheng, Xiaoyuan (Zheng, Xiaoyuan.) [2] | Tan, Xionghong (Tan, Xionghong.) [3] | Ke, Kun (Ke, Kun.) [4] | Wang, Fei (Wang, Fei.) [5] | Wang, Yingchao (Wang, Yingchao.) [6] | Xing, Xiaohua (Xing, Xiaohua.) [7] | Zhang, Cuilin (Zhang, Cuilin.) [8] | Hu, Ping (Hu, Ping.) [9] | Lan, Shubing (Lan, Shubing.) [10] | Li, Qin (Li, Qin.) [11] | Huang, Aimin (Huang, Aimin.) [12] | Liu, Xiaolong (Liu, Xiaolong.) [13]

Indexed by:

Scopus SCIE

Abstract:

SALL4 and OCT4, along with other pluripotency-associated transcription factors, play critical roles in maintaining embryonic stem cell pluripotency and self-renewal. Ku80 is a component of the protein complex called DNA-dependent protein kinase, which mainly involved in DNA double-strand break repair. In this study, we show evidence that Ku80 physically interacted with SALL4. The interaction competitively disrupts the SALL4-OCT4 complex and result in OCT4 lysosomal degradation. Finally, Ku80 inhibits self-renewal and metastasis of hepatocellular carcinoma cells through breaking the SALL4-OCT4 interactions and down-regulating the expression of OCT4. Our study reveal novel function of Ku80 in sternness maintaining of cancer stern cells via its interaction with SALL4 and highlight the double-sidedness of Ku80 as an anti-cancer target.

Keyword:

Ku80 Lysosomal degradation OCT4 SALL4 Stemness

Community:

  • [ 1 ] [Zhao, Bixing]Fujian Med Univ, Mengchao Hepatobiliary Hosp, United Innovat Mengchao Hepatobiliary Technol Key, Fuzhou 350025, Peoples R China
  • [ 2 ] [Zheng, Xiaoyuan]Fujian Med Univ, Mengchao Hepatobiliary Hosp, United Innovat Mengchao Hepatobiliary Technol Key, Fuzhou 350025, Peoples R China
  • [ 3 ] [Tan, Xionghong]Fujian Med Univ, Mengchao Hepatobiliary Hosp, United Innovat Mengchao Hepatobiliary Technol Key, Fuzhou 350025, Peoples R China
  • [ 4 ] [Ke, Kun]Fujian Med Univ, Mengchao Hepatobiliary Hosp, United Innovat Mengchao Hepatobiliary Technol Key, Fuzhou 350025, Peoples R China
  • [ 5 ] [Wang, Fei]Fujian Med Univ, Mengchao Hepatobiliary Hosp, United Innovat Mengchao Hepatobiliary Technol Key, Fuzhou 350025, Peoples R China
  • [ 6 ] [Wang, Yingchao]Fujian Med Univ, Mengchao Hepatobiliary Hosp, United Innovat Mengchao Hepatobiliary Technol Key, Fuzhou 350025, Peoples R China
  • [ 7 ] [Xing, Xiaohua]Fujian Med Univ, Mengchao Hepatobiliary Hosp, United Innovat Mengchao Hepatobiliary Technol Key, Fuzhou 350025, Peoples R China
  • [ 8 ] [Zhang, Cuilin]Fujian Med Univ, Mengchao Hepatobiliary Hosp, United Innovat Mengchao Hepatobiliary Technol Key, Fuzhou 350025, Peoples R China
  • [ 9 ] [Hu, Ping]Fujian Med Univ, Mengchao Hepatobiliary Hosp, United Innovat Mengchao Hepatobiliary Technol Key, Fuzhou 350025, Peoples R China
  • [ 10 ] [Lan, Shubing]Fujian Med Univ, Mengchao Hepatobiliary Hosp, United Innovat Mengchao Hepatobiliary Technol Key, Fuzhou 350025, Peoples R China
  • [ 11 ] [Li, Qin]Fujian Med Univ, Mengchao Hepatobiliary Hosp, United Innovat Mengchao Hepatobiliary Technol Key, Fuzhou 350025, Peoples R China
  • [ 12 ] [Liu, Xiaolong]Fujian Med Univ, Mengchao Hepatobiliary Hosp, United Innovat Mengchao Hepatobiliary Technol Key, Fuzhou 350025, Peoples R China
  • [ 13 ] [Hu, Ping]Fujian Med Univ, Sch Basic Med Sci, Fuzhou 350108, Peoples R China
  • [ 14 ] [Huang, Aimin]Fujian Med Univ, Sch Basic Med Sci, Fuzhou 350108, Peoples R China
  • [ 15 ] [Zhao, Bixing]Fuzhou Univ, Mengchao Med X Ctr, Fuzhou 350116, Peoples R China
  • [ 16 ] [Wang, Yingchao]Fuzhou Univ, Mengchao Med X Ctr, Fuzhou 350116, Peoples R China
  • [ 17 ] [Xing, Xiaohua]Fuzhou Univ, Mengchao Med X Ctr, Fuzhou 350116, Peoples R China
  • [ 18 ] [Zhang, Cuilin]Fuzhou Univ, Mengchao Med X Ctr, Fuzhou 350116, Peoples R China
  • [ 19 ] [Liu, Xiaolong]Fuzhou Univ, Mengchao Med X Ctr, Fuzhou 350116, Peoples R China
  • [ 20 ] [Zhao, Bixing]Fujian Med Univ, Liver Ctr Fujian Prov, Fuzhou 350025, Peoples R China
  • [ 21 ] [Zheng, Xiaoyuan]Fujian Med Univ, Liver Ctr Fujian Prov, Fuzhou 350025, Peoples R China
  • [ 22 ] [Tan, Xionghong]Fujian Med Univ, Liver Ctr Fujian Prov, Fuzhou 350025, Peoples R China
  • [ 23 ] [Ke, Kun]Fujian Med Univ, Liver Ctr Fujian Prov, Fuzhou 350025, Peoples R China
  • [ 24 ] [Wang, Fei]Fujian Med Univ, Liver Ctr Fujian Prov, Fuzhou 350025, Peoples R China
  • [ 25 ] [Wang, Yingchao]Fujian Med Univ, Liver Ctr Fujian Prov, Fuzhou 350025, Peoples R China
  • [ 26 ] [Xing, Xiaohua]Fujian Med Univ, Liver Ctr Fujian Prov, Fuzhou 350025, Peoples R China
  • [ 27 ] [Zhang, Cuilin]Fujian Med Univ, Liver Ctr Fujian Prov, Fuzhou 350025, Peoples R China
  • [ 28 ] [Hu, Ping]Fujian Med Univ, Liver Ctr Fujian Prov, Fuzhou 350025, Peoples R China
  • [ 29 ] [Lan, Shubing]Fujian Med Univ, Liver Ctr Fujian Prov, Fuzhou 350025, Peoples R China
  • [ 30 ] [Li, Qin]Fujian Med Univ, Liver Ctr Fujian Prov, Fuzhou 350025, Peoples R China
  • [ 31 ] [Huang, Aimin]Fujian Med Univ, Liver Ctr Fujian Prov, Fuzhou 350025, Peoples R China
  • [ 32 ] [Liu, Xiaolong]Fujian Med Univ, Liver Ctr Fujian Prov, Fuzhou 350025, Peoples R China

Reprint 's Address:

  • 刘小龙

    [Liu, Xiaolong]Xihong Rd 312, Fuzhou 350025, Peoples R China;;[Huang, Aimin]Xueyuan Rd 1, Fuzhou 350108, Peoples R China

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Source :

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

ISSN: 1357-2725

Year: 2020

Volume: 118

5 . 0 8 5

JCR@2020

3 . 4 0 0

JCR@2023

ESI Discipline: BIOLOGY & BIOCHEMISTRY;

ESI HC Threshold:156

JCR Journal Grade:2

CAS Journal Grade:3

Cited Count:

WoS CC Cited Count: 3

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 0

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