The　development　of　cost-effective　methanol　oxidation　reaction　(MOR)　catalysts　with　a　high　activity　and　stability　is　highly　desirable　for　direct　methanol　fuel　cells.　In　this　study,　the　structurally　ordered　PtSn　intermetallic　nanoparticles　supported　on　Sb-doped　SnO2　(ATO)　have　been　successfully　synthesized　in　ethylene　glycol　(EG)　solution　at　200　degrees　C.　Pt　NPs　were　firstly　formed　on　ATO,　followed　by　the　transformation　from　Pt　into　hexagonal　PtSn　on　the　surface　of　ATO.　The　obtained　structurally　ordered　PtSn　intermetallic　NPs　supported　on　ATO　demonstrate　significantly　enhanced　MOR　activity　and　durability　in　comparison　with　commercial　Pt/C.　Our　PtSn　intermetallic　NPs　supported　on　ATO　show　a　MOR　activity　4.1　times　higher　than　that　of　commercial　Pt/C　catalysts.　Accelerated　durability　tests　indicate　that　the　commercial　Pt/C　catalysts　lose　about　50%　of　their　initial　current　density　after　500　cycles　while　the　Pt/ATO-200-3　h　catalyst　loses　only　about　15%　of　its　initial　current　density.　Our　PtSn　intermetallic　NPs　supported　on　ATO　are　also　found　to　have　higher　CO　tolerance　than　commercial　Pt/C.　This　work　demonstrates　an　important　strategy　to　rationally　design　high-performance　structurally　ordered　Pt-based　intermetallic　NP　catalysts　for　fuel　cells　and　other　applications.