Although　photothermal　therapy　(PTT)　is　preclinically　applied　in　solid　tumor　treatment,　incomplete　tumor　removal　of　PTT　and　heat　endurance　of　tumor　cells　induces　significant　tumor　relapse　after　treatment,　therefore　lowering　the　therapeutic　efficiency　of　PTT.　Herein,　a　programmable　therapeutic　strategy　that　integrates　photothermal　therapeutic　agents　(PTAs),　DNAzymes,　and　artificial　engineered　natural　killer　(A-NK)　cells　for　immunotherapy　of　hepatocellular　carcinoma　(HCC)　is　designed.　The　novel　PTAs,　termed　as　Mn-CONASHs,　with　2D　structure　are　synthesized　by　the　coordination　of　tetrahydroxyanthraquinone　and　Mn2+　ions.　By　further　adsorbing　polyetherimide/DNAzymes　on　the　surface,　the　DNAzymes@Mn-CONASHs　exhibit　excellent　light-to-heat　conversion　ability,　tumor　microenvironment　enhanced　T-1-MRI　guiding　ability,　and　antiheat　endurance　ability.　Furthermore,　the　artificial　engineered　NK　cells　with　HCC　specific　targeting　TLS11a-aptamer　decoration　are　constructed　for　specifically　eliminating　any　possible　residual　tumor　cells　after　PTT,　to　systematically　enhance　the　therapeutic　efficacy　of　PTT　and　avoid　tumor　relapse.　Taken　together,　the　potential　of　A-NK　cells　combined　with　antiheat　endurance　as　a　powerful　strategy　for　immuno-enhancing　photothermal　therapy　efficiency　of　solid　tumors　is　highlighted,　and　the　current　strategy　might　provide　promising　prospects　for　cancer　therapy.