Bimetallic　CuPd　nanoclusters　with　a　small　size　of　approximate　to　0.9　nm　are　encapsulated　inside　cavities　of　NH2-UiO-66(Zr)　via　double-solvent　impregnation,　followed　by　a　reduction　process　with　NaBH4.　As　compared　with　monometallic　Pd@NH2-UiO-66(Zr),　bimetallic　CuPd@NH2-UiO-66(Zr)　shows　superior　performance　for　light-induced　Suzuki　coupling　reaction　since　the　introduced　Cu　acts　as　an　electron　mediator　to　facilitate　the　transfer　of　photogenerated　electrons　from　light-excited　NH2-UiO-66(Zr)　to　Pd,　to　form　electron-rich　Pd.　Moreover,　CuPd@NH2-UiO-66(Zr)　also　shows　higher　activity　than　CuPd/NH2-UiO-66(Zr),　in　which　CuPd　nanoparticles　are　deposited　on　the　surface　of　NH2-UiO-66(Zr).　The　as-obtained　CuPd@NH2-UiO-66(Zr)　is　stable　and　can　be　applied　in　the　coupling　of　a　variety　of　substituted　iodobenzenes　and　phenylboronic　acids.　The　simultaneous　encapsulation　of　metallic　Pd　and　Cu,　acting　as　a　catalytic　active　site　and　mediator　respectively,　inside　the　cavities　of　NH2-UiO-66(Zr),　represents　a　novel　strategy　for　designing　multifunctional　metal-organic　framework　based　catalysts　for　light-induced　organic　reactions.