In　digital　printing,　a　high　salt　content　in　dye　solutions　is　detrimental,　which　calls　for　effective　strategy　for　dye/salt　fractionation.　In　this　study,　a　loose　nanofiltration　(NF)　membrane　Sepro　2A　was　employed　to　desalinate　diverse　dye　species　(2　reactive　dyes　and　4　cationic　dyes).　This　membrane,　with　a　molecular　weight　cutoff　of　490　Da,　showed　consistently　high　rejections　to　all　the　reactive　and　cationic　dyes　(＞97.7%).　Operational　conditions　such　as　dye　concentrations　and　applied　pressures　have　limited　effects　on　the　rejection　of　the　membrane.　An　integrated　NF-diafiltration　process,　involving　a　pre-concentration　and　a　diafiltration　step,　was　specifically　designed　for　the　fractionation　of　dye/NaCl　mixtures.　This　loose　NF　membrane　showed　＞99.7%　rejection　to　reactive　dyes　(reactive　blue　2　and　reactive　orange　16)　and　ca.　99.3%　salt　removal　with　ca.　2.0%　dye　loss　after　5.0　diavolumes.　However,　the　NF　membrane　experienced　a　15.9%　loss　to　methylene　blue　due　to　the　lower　rejection　to　this　model　cationic　dye　(97.2%).　The　current　study　provides　important　insights　into　dye/salt　fractionation　by　loose　NF　membranes　for　digital　ink-jet　printing.