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Abstract:
A protocol for palladium-catalyzed C-H carbonylation of readily available free primary benzylamines using NH2 as the chelating group under an atmospheric pressure of CO has been achieved, providing a general, atom- and step-economic approach to benzolactams, an important structural motif found in many biologically active compounds. Application of this new method is also exemplified in the concise syntheses of two bioactive molecules.
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ORGANIC LETTERS
ISSN: 1523-7060
Year: 2018
Issue: 9
Volume: 20
Page: 2595-2598
6 . 5 5 5
JCR@2018
4 . 9 0 0
JCR@2023
ESI Discipline: CHEMISTRY;
ESI HC Threshold:209
JCR Journal Grade:1
CAS Journal Grade:1
Cited Count:
WoS CC Cited Count: 58
SCOPUS Cited Count: 60
ESI Highly Cited Papers on the List: 0 Unfold All
WanFang Cited Count:
Chinese Cited Count:
30 Days PV: 1
Affiliated Colleges: