A　2D　porous　media　Computational　Fluid　Dynamics　(CFD)　model　is　developed　for　a　fixed　bed　adsorber　to　remove　the　4,6-dimethyldibenzothiophene　(4,6-DMDBT)　from　diesel.　The　Ag-TiO2-SiO2　modified　by　CeOx　adsorbent　is　used　to　remove　the　4,6-DMDBT　from　diesel　and　proves　that　CeOx　species　could　promote　high　dispersion　of　Ag　species　on　adsorbent　surface.　The　mass　source　term　describing　mass　transfer　of　4,6-DMDBT　inside　the　adsorption　bed　column　is　considered.　The　effects　of　various　parameters　such　as　feed　concentration,　feed　rate　and　column　height　on　adsorption　process　have　been　investigated.　Mesh　independent　test　is　performed　to　investigate　the　effect　of　the　grid　size　on　the　simulation　results.　The　component　distribution　contour　and　mass　transfer　rate　are　employed　to　analyse　further　the　mass　transfer　phenomenon　in　fixed　bed　column.　The　higher　mass　transfer　rate　at　the　beginning　can　be　observed　and　the　lower　mass　transfer　rate　is　obtained　after　a　period　of　adsorption　time　at　high　feed　concentration.　Results　also　demonstrate　that　the　porous　media　CFD　model　can　successfully　describe　the　adsorption　of　4,6-DMDBT　from　diesel　in　fixed　bed　column.　Finally,　the　results　of　Genetic　algorithm　search　suggest　that　the　optimal　height　of　mass　transfer　zone　can　be　got　at　low　feed　rate,　high　bed　height　and　low　feed　concentration.