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Multiresponsive and biocompatible self-healing epsilon-PL/A-Pul/BPEI hydrogels were prepared in aqueous solution by Schiff base reaction with aldehyded pullulan (A-Pul), epsilon-poly-(l)-lysine (epsilon- PL) and branched polyethyleneimine (BPEI) as materials. The imine bonds were rapidly cross-linked into a hydrogel network within 80 s. Scanning electron microscopy images showed that the hydrogels exhibited a cross-linked structure with the average pore size from 58 to 82 mm. Rheology tests indicated that the hydrogels maintained good mechanical properties. Water contact angles and swelling studies suggested that the hydrogels could swell in water, with a max swell ratio of 1559%, and pH and temperature had an influence on the equilibrium swelling ratio. The hydrogels could be injected either before or after gelation, and they displayed a self-healing process in ddH(2)O at room temperature based on the dynamic uncoupling and recoupling of the imine bonds. The MTT assays implied that the hydrogels were non-cytotoxic on mice bone marrow mesenchymal stem cells. Therefore, the hydrogels showed potential application in biomedical fields, and consequently further work was performed using the self-healing hydrogels as drug carriers in in vitro/vivo antitumor studies.
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SOFT MATTER
ISSN: 1744-683X
Year: 2017
Issue: 16
Volume: 13
Page: 3003-3012
3 . 7 0 9
JCR@2017
2 . 9 0 0
JCR@2023
ESI Discipline: MATERIALS SCIENCE;
ESI HC Threshold:306
JCR Journal Grade:1
CAS Journal Grade:2
Cited Count:
WoS CC Cited Count: 45
SCOPUS Cited Count: 48
ESI Highly Cited Papers on the List: 0 Unfold All
WanFang Cited Count:
Chinese Cited Count:
30 Days PV: 1
Affiliated Colleges: