A　generalized　collaborative　optimization　(CO)　framework　is　proposed　to　the　optimization　design　of　the　lines　of　an　underwater　vehicle.　The　resistance　and　maneuvering　performances　are　concerned　about　and　taken　as　the　optimization　objectives　in　the　optimization　framework.　The　resistance,　lateral　force　and　yaw　moment　are　calculated　by　RANS　method.　To　improve　the　optimization　efficiency,　an　automatic　integration　optimization　platform　is　constructed　in　which　a　surrogate　model　is　adopted.　A　SUBOFF　model　is　taken　as　the　verification　model.　The　optimal　results　demonstrate　the　validity　of　the　optimization　strategy　proposed.