A　fluid-particles　system　of　the　compressible　Navier-Stokes　equations　and　Vlasov-Fokker-Planck　equation　(including　the　case　of　Vlasov　equation)　in　three-dimensional　space　is　considered　in　this　paper.　The　coupling　arises　from　a　drag　force　exerted　by　the　fluid　onto　the　particles.　We　study　a　Cauchy　problem　with　large　data,　and　establish　the　existence　of　global　weak　solutions　through　an　approximation　scheme,　energy　estimates,　and　weak　convergence.　Copyright　(c)　2016John　Wiley　&　Sons,　Ltd.