A　rare　hexacyclic　oxindole　alkaloid,　speradine　F　(1),　together　with　two　novel　tetracyclic　oxindole　alkaloids,　speradines　G　(2)　and　H　(3),　were　isolated　from　the　marine-derived　fungus　Aspergillus　oryzae.　Their　structures　were　determined　by　spectroscopic　methods　and　X-ray　diffraction　analysis.　This　study　is　the　first　report　on　cyclopiazonic　acid　(CPA)-type　alkaloids　with　a　hexacyclic　skeleton.