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author:

Lin, Zian (Lin, Zian.) [1] (Scholars:林子俺) | Tan, Xiaoqing (Tan, Xiaoqing.) [2] | Yu, Ruifang (Yu, Ruifang.) [3] | Lin, Jiashi (Lin, Jiashi.) [4] | Yin, Xiaofei (Yin, Xiaofei.) [5] | Zhang, Lan (Zhang, Lan.) [6] (Scholars:张兰) | Yang, Huanghao (Yang, Huanghao.) [7] (Scholars:杨黄浩)

Indexed by:

EI Scopus SCIE

Abstract:

A novel glutathione (GSH)-silica hybrid monolithic column synthesized via a combination of thiolene click reaction and one-pot process was described, where thiol-end GSH organic monomer and 2,2-azobisisobutyronitrile (AIBN) were mixed with hydrolyzed tetramethyloxysilane (TMOS) and gamma-methacryloxypropyltrimethoxysilane (gamma-MAPS) and then introduced into a fused-silica capillary for simultaneous polycondensation and "thiol-ene" click reaction to form the GSH-silica hybrid monolith. The effects of the molar ratio of TMOS/gamma-MAPS, the amount of GSH, and the volume of porogen on the morphology, permeability and pore properties of the prepared GSH-silica hybrid monoliths were studied in detail. A uniform monolithic network with high porosity was obtained. A series of test compounds including alkylbenzenes, amides, and anilines were used to evaluate the retention behaviors of the GSH-silica hybrid monolithic column. The results demonstrated that the prepared GSH-silica hybrid monolith exhibited multiple interactions including hydrophobicity, hydrophilicity, as well as cation exchange interaction. The run-to-run, column-to-column and batch-to-batch reproducibilities of the GSH-silica hybrid monolith for phenols' retention were satisfactory with the relative standard deviations (RSDs) less than 1.3% (n=5), 2.6% (n =3) and 3.2% (n=3), respectively, indicating the effectiveness and practicability of the proposed method. In addition, the GSH-silica hybrid monolith was applied to the separation of nucleotides, peptides and protein tryptic digests, respectively. The successful applications suggested the potential of the GSH-silica hybrid monolith in complex sample analysis. (C) 2014 Elsevier B.V. All rights reserved.

Keyword:

Capillary liquid chromatography Click chemistry Glutathione Mixed-mode One-pot Organic-inorganic hybrid monolith

Community:

  • [ 1 ] [Lin, Zian]Fuzhou Univ, Coll Chem, Fujian Prov Key Lab Anal & Detect Technol Food Sa, Minist Educ,Key Lab Anal & Detect Food Safety, Fuzhou 350116, Fujian, Peoples R China
  • [ 2 ] [Tan, Xiaoqing]Fuzhou Univ, Coll Chem, Fujian Prov Key Lab Anal & Detect Technol Food Sa, Minist Educ,Key Lab Anal & Detect Food Safety, Fuzhou 350116, Fujian, Peoples R China
  • [ 3 ] [Yu, Ruifang]Fuzhou Univ, Coll Chem, Fujian Prov Key Lab Anal & Detect Technol Food Sa, Minist Educ,Key Lab Anal & Detect Food Safety, Fuzhou 350116, Fujian, Peoples R China
  • [ 4 ] [Zhang, Lan]Fuzhou Univ, Coll Chem, Fujian Prov Key Lab Anal & Detect Technol Food Sa, Minist Educ,Key Lab Anal & Detect Food Safety, Fuzhou 350116, Fujian, Peoples R China
  • [ 5 ] [Yang, Huanghao]Fuzhou Univ, Coll Chem, Fujian Prov Key Lab Anal & Detect Technol Food Sa, Minist Educ,Key Lab Anal & Detect Food Safety, Fuzhou 350116, Fujian, Peoples R China
  • [ 6 ] [Lin, Jiashi]Jimei Univ, Coll Phys Educ, Xiamen 361021, Peoples R China
  • [ 7 ] [Yin, Xiaofei]SOA, Inst Oceanog 1, Qingdao 266061, Peoples R China

Reprint 's Address:

  • 林子俺

    [Lin, Zian]Fuzhou Univ, Coll Chem, Fuzhou 350116, Fujian, Peoples R China

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Source :

JOURNAL OF CHROMATOGRAPHY A

ISSN: 0021-9673

Year: 2014

Volume: 1355

Page: 228-237

4 . 1 6 9

JCR@2014

3 . 8 0 0

JCR@2023

ESI Discipline: CHEMISTRY;

ESI HC Threshold:268

JCR Journal Grade:1

CAS Journal Grade:2

Cited Count:

WoS CC Cited Count: 49

SCOPUS Cited Count: 52

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 1

Online/Total:188/10012301
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