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author:

Lin, Yueqiong (Lin, Yueqiong.) [1] (Scholars:林月琼) | Cheung, Siu Hung (Cheung, Siu Hung.) [2] | Poon, Wai-Yin (Poon, Wai-Yin.) [3] | Lu, Tong-Yu (Lu, Tong-Yu.) [4]

Indexed by:

Scopus SCIE

Abstract:

Clinical trials frequently involve pairwise comparisons of different treatments to evaluate their relative efficacy. In this study, we examine methods for conducting pairwise tests of treatments with ordered categorical responses. A modified version of the Wilcoxon-Mann-Whitney test based on a logistic regression model assuming proportional odds is a popular choice for comparing two treatments. This paper discusses the extension of this test to pairwise comparisons involving more than two treatments. However, when the proportional odds assumption is not valid, the Wilcoxon-Mann-Whitney-type test procedure cannot control the overall type I error rate at the prespecified level of significance. We therefore propose a better strategy in which a latent normal model is employed. We presented a simulated comparative study of power and the overall type I error rate to illustrate the superiority of the latent normal model. Examples are also given for illustrative purposes. Copyright (c) 2013 John Wiley & Sons, Ltd.

Keyword:

familywise error rate latent variable model log-odds ratio ordered categorical response proportional odds model

Community:

  • [ 1 ] [Lin, Yueqiong]Fuzhou Univ, Sch Management, Fuzhou 350002, Peoples R China
  • [ 2 ] [Cheung, Siu Hung]Chinese Univ Hong Kong, Dept Stat, Shatin, Hong Kong, Peoples R China
  • [ 3 ] [Poon, Wai-Yin]Chinese Univ Hong Kong, Dept Stat, Shatin, Hong Kong, Peoples R China
  • [ 4 ] [Lu, Tong-Yu]China Jiliang Univ, Coll Econ & Management, Hangzhou, Zhejiang, Peoples R China

Reprint 's Address:

  • [Cheung, Siu Hung]Chinese Univ Hong Kong, Dept Stat, Shatin, Hong Kong, Peoples R China

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Source :

STATISTICS IN MEDICINE

ISSN: 0277-6715

Year: 2013

Issue: 18

Volume: 32

Page: 3192-3205

2 . 0 3 7

JCR@2013

1 . 8 0 0

JCR@2023

ESI Discipline: SOCIAL SCIENCES, GENERAL;

JCR Journal Grade:1

CAS Journal Grade:2

Cited Count:

WoS CC Cited Count: 0

SCOPUS Cited Count: 13

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 2

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