A　novel　nonenzymatic　glucose　sensor　based　on　flower-shaped　(FS)　Au@Pd　core-shell　nanoparticles-ionic　liquids　(ILs　i.e.,　trihexyltetradecylphosphonium　bis(trifluoromethylsulfonyl)　imide,　[P(C-6)(3)C-14][Tf2N])　composite　film　modified　glassy　carbon　electrodes　(GCE)　was　reported.　The　Au@Pd　nanocatalysts　were　prepared　by　seed-mediated　growth　method,　forming　the　three-dimensional　FS　nanoparticles,　where　tens　of　small　Pd　nanoparticles　(similar　to　3　nm)　aggregated　on　gold　seeds　(similar　to　20　nm).　The　FS　Au@Pd　nanoparticle　was　a　good　candidate　for　the　catalytic　efficiency　of　nanometallic　surfaces　because　of　its　flower-shaped　nature,　which　has　greater　adsorption　capacity.　XPS　analysis　and　zeta　potential　indicated　that　the　surface　of　Pd　atoms　is　positively　charged,　profiting　the　oxidation　process　of　glucose.　And　ILs　acted　as　bridge　connecting　Au@Pd　one　another　and　bucky　gel　as　platform　within　the　whole　nanocomposite.　So　the　modified　electrode　has　higher　sensitivity　and　selectivity　owing　to　intrinsic　synergistic　effects　of　this　nanocomposite.　Amperometric　measurements　allow　observation　of　the　electrochemical　oxidation　of　glucose　at　0.0　V　(vs.　Ag/AgCl),　the　glucose　oxidation　current　is　linear　to　its　concentration　in　the　range　of　5　nM-0.5　mu　M,　and　the　detection　limit　was　found　to　be　1.0　nM　(S/N　=　3).　The　as-prepared　nonenzyme　glucose　sensor　exhibited　excellent　stability,　repeatability,　and　selectivity.　(C)　2010　Elsevier　Ltd.　All　rights　reserved.