A　simple,　sensitive,　and　quick　method　was　established　to　separate　and　determine　two　beta-blockers,　sotalol　and　celiprolol　in　human　urine　by　capillary　electrophoresis-amperometric　detection.　Under　optimal　conditions　of　the　detection　potential　of　300　mu　m　platinum　disk　electrode　at　0.　950　V　(vs.　Ag/AgCl)　pH　9.　60,　30　mmol/L　Clark-Lubs　buffer　solution,　the　two　analytes　were　baseline　separated　in　8　min.　The　calibration　curves　exhibited　an　excellent　linear　behavior　over　the　concentration　range　about　three　orders　of　magnitude.　The　detection　limits　were　0.　05　and　0.　09　mg/L　for　sotalol　and　celiprolol,　respectively.　The　method　was　Successfully　applied　to　the　detection　of　sotalol　in　the　human　urine　after　36　h　of　administration　of　sotalol　tablets,　and　the　metabolism　curve　of　it　was　also　obtained.