The　title　compound　[VS4Cu6Py8I3]　was　obtained　in　the　reaction　system　(NH4)(3)VS4/CuI/Py　and　its　crystal　structure　has　been　determined　by　single-crystal　X-ray　diffraction.　It　crystallizes　in　orthorhombic,　space　group　Fdd2　with　a　=　29.924(6),　b　=　13.475(3),　c　=　25.853(5)　Angstrom,　V　=　10425(4)　Angstrom(3),　D-c　=　2.006　g/cm(3),　M-r　=　1573.92,　Z　=　8,　mu(MoKalpha)　=　4.546　mm(-1)　and　F(000)　=　6048.　The　structure　was　solved　by　direct　methods　and　refined　by　full-matrix　least-squares　technique　to　the　final　R　=　0.023　and　wR　=　0.069.　Six　Cu　atoms　form　an　octahedron　with　the　V　atom　nearly　located　at　the　center.　All　of　the　three　I　atoms　are　terminal　ligands.　The　C-2　symmetry　axis　is　found　in　the　molecule.