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author:

Zhu, Jia (Zhu, Jia.) [1] | Lin, Guanzhou (Lin, Guanzhou.) [2] | Wang, Runhua (Wang, Runhua.) [3] | Huang, Yun (Huang, Yun.) [4] | Chen, Zhuojie (Chen, Zhuojie.) [5] | Chen, Xiaoyu (Chen, Xiaoyu.) [6] | Liu, Peimin (Liu, Peimin.) [7] | Wu, Wengang (Wu, Wengang.) [8]

Indexed by:

CPCI-S

Abstract:

Visual and real-time plasmonic metamaterial biosensors, relying on surface plasmon resonance (SPR) on metallic subwavelength structures, have significant potential for colorimetric biochemical sensing by simple instrumentation or even naked eye. In this paper, we present a visual and real-time sensing strategy for the detection of the biotin-avidin-system (BAS), which is a powerful tool in biological sciences. The metamaterial, consisting of an array of three-dimensional all-metal nano-cavities, can confine the light into the near field and enable strong light-matter interactions there. Therefore, The metamaterial shows significant color shifts with small refraction index changes. When a monomolecular layer of thiolated biotin and streptavidin bonding to the surface of the nanostructure successively, the color of the metamaterials changes from red to violet and then loden. This sensing strategy offers new opportunities for convenient detection of proteins, nucleic acids and lipids.

Keyword:

BAS detection metamaterial surface plasmon resonance (SPR)

Community:

  • [ 1 ] [Zhu, Jia]Peking Univ, Inst Microelect, Natl Key Lab Sci & Technol Micro Nano Fabricat, Beijing 100871, Peoples R China
  • [ 2 ] [Wang, Runhua]Peking Univ, Inst Microelect, Natl Key Lab Sci & Technol Micro Nano Fabricat, Beijing 100871, Peoples R China
  • [ 3 ] [Huang, Yun]Peking Univ, Inst Microelect, Natl Key Lab Sci & Technol Micro Nano Fabricat, Beijing 100871, Peoples R China
  • [ 4 ] [Chen, Zhuojie]Peking Univ, Inst Microelect, Natl Key Lab Sci & Technol Micro Nano Fabricat, Beijing 100871, Peoples R China
  • [ 5 ] [Chen, Xiaoyu]Peking Univ, Inst Microelect, Natl Key Lab Sci & Technol Micro Nano Fabricat, Beijing 100871, Peoples R China
  • [ 6 ] [Wu, Wengang]Peking Univ, Inst Microelect, Natl Key Lab Sci & Technol Micro Nano Fabricat, Beijing 100871, Peoples R China
  • [ 7 ] [Lin, Guanzhou]Fuzhou Univ, Coll Phys & Informat Engn, Fuzhou 350108, Fujian, Peoples R China
  • [ 8 ] [Liu, Peimin]Fuzhou Univ, Coll Phys & Informat Engn, Fuzhou 350108, Fujian, Peoples R China

Reprint 's Address:

  • [Wu, Wengang]Peking Univ, Inst Microelect, Natl Key Lab Sci & Technol Micro Nano Fabricat, Beijing 100871, Peoples R China

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Source :

2019 20TH INTERNATIONAL CONFERENCE ON SOLID-STATE SENSORS, ACTUATORS AND MICROSYSTEMS & EUROSENSORS XXXIII (TRANSDUCERS & EUROSENSORS XXXIII)

Year: 2019

Page: 1132-1135

Language: English

Cited Count:

WoS CC Cited Count: 0

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 5

Online/Total:121/10018934
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