High-sensitivity　C-reactive　protein　(hs-CRP)　performs　important　roles　on　the　onset　of　metabolic　syndrome　and　cardiovascular　diseases　(CVD),　but　little　is　known　about　association　between　hs-CRP　and　obesity-related　metabolic　abnormalities　in　young　people　without　classical　CVD　risk　factors.　It　thus　motivated　us　to　investigate　association　among　hs-CRP,　body　fat　mass　(FM)　distribution,　and　other　cardiometabolic　risk　factors　in　young　healthy　women.　Our　approach　is　based　on　biological　experiments,　statistical　analysis,　and　semantic　search.　Research　outcomes　in　this　study　resulted　in　two　novel　discoveries.　Discovery　1:　There　are　four　primary　determinants　for　hs-CRP,　i.e.,　central/abdominal　FM　(a.k.a.　trunk　FM)　accumulation,　leptin,　high　density　lipoprotein　cholesterol　(HDL-C),　and　plasminogen　activator　inhibitior-1　(PAI1).　Discovery　2:　Chronic　inflammation　may　involve　in　adipocyte-cytokine　interaction　underlying　the　metabolic　derangement　in　healthy　young　women.