In　this　paper,　a　multi-level　method　has　been　adopted　to　optimize　the　holes　machining　process　with　genetic　algorithm　(GA).　Based　on　the　analyzing　of　the　features　of　the　part　with　multi-holes,　the　local　optimal　processing　route　for　the　holes　with　the　same　processing　feature　is　obtained　with　GA,　then　try　to　obtain　the　global　optimal　route　with　GA　by　considering　the　obtained　local　optimal　route　and　the　holes　with　different　features.　That　is　what　the　multi-level　method　means.　The　optimal　route　means　the　minimum　moving　length　of　the　cutting　tool　and　the　minimum　changing　times　of　the　cutting　tool.　The　experiment　is　carried　out　to　verify　the　algorithm　and　the　proposed　method,　and　result　indicates　that　with　GA　and　using　the　multi-level　method　the　optimal　holes　machining　route　can　be　achieved　efficiently.