The　adsorption　statics　and　kinetics　of　sisomicin　on　macroporous　weakly　basic　acid　resin　were　studied.　The　batch　adsorption　equilibrium　data　were　measured　in　experimental　condition.　The　linear　driving　force　(LDF)　model　was　established　to　simulate　the　adsorption　process　of　sisomicin　on　the　exchange　resin　D113.　The　intraparticle　surface　diffusion　coefficient　was　obtained　by　regression　of　the　experimental　data　of　adsorption　rate　curves　compared　with　least　square　method　and　genetic　algorithms.　The　mean　square　errors　were　not　more　than　0.03.　The　results　showed　that　the　numerical　solutions　were　in　agreement　with　the　experimental　data　of　adsorption　rate　curves.　The　adsorption　process　could　be　described　with　the　linear　driving　force　model　very　well.　The　intraparticle　effective　diffusion　coefficient　was　evaluated　by　a　genetic　algorithm.　The　intraparticle　effective　diffusion　coefficient　was　determined　to　be　1.7　X　10(-8)　similar　to　3.7　X　10(-8)　cm(2.)s(-1)　under　experimental　condition.　The　internal　mass　transfer　resistance　was　the　rate-determining　step.