Cocatalyst　loading　is　widely　used　as　an　approach　in　photocatalysis　to　expedite　photoinduced　charge　separation　and　interfacial　oxidation-reduction　kinetics,　which　are　crucial　factors　for　affecting　redox　catalysis　efficiency　over　semiconductor-based　photocatalysts.　However,　tackling　the　key　problem　of　cocatalyst　loading　position　over　heterojunction　photocatalysts　is　still　a　great　challenge.　We　herein　report　a　facile　and　general　light-tuning　photodeposition　strategy　to　realize　site-directed　spatial　loading　of　diverse　cocatalysts　(MoS2,　NixS,　NixO,　NixP,　Pt)　onto　a　CdS/TiO2　heterojunction　photocatalyst,　thereby　abating　surface　charge　recombination　and　markedly　improving　the　photoredox-catalyzed　activity　of　hydrogen　evolution　and　selective　oxidation　of　alcohol.　This　work　highlights　the　wide　scope　of　manipulating　light　to　spatially　regulate　the　cocatalyst　loading　position,　thereby　optimizing　surface/interface　charge　recombination　dynamics　and　ameliorating　the　net　efficiency　of　charge　separation　and　photoredox　catalysis.　Copyright　©　2020　American　Chemical　Society.