The　molecular　mechanism　of　platinum-based　drugs　in　concomitant　chemoradiation　therapy　relies　on　enhancement　of　DNA　damage　in　cancer　cells,　particularly　that　of　detrimental　clustered　lesions　and　cross-links　induced　by　the　abundant　low-energy　electrons　(LEEs)　generated　by　ionizing　radiation.　We　provide　the　complete　1-20　eV　electron-energy　dependence　of　the　yields　of　all　conformational　LEE-induced　lesions　to　biological　DNA,　when　it　binds　to　five　molecules　of　the　chemotherapeutic　drug　cisplatin.　Recording　at　1　eV　intervals　clearly　show　that　the　enhancement　of　all　lesions　is　particularly　intense　at　the　energies　of　core-excited　transient　molecular　anions　(i.e.,　TMAs　at　5,　6,　and　10　eV).　New　TMAs　are　observed　at　14　and　18　eV,　only　in　yield　functions　of　cisplatin-DNA　complexes.　Enhancements　of　all　lesions　by　cisplatin　are　quantified　over　the　1-20　eV　range,　where　maxima　appear　at　14　and　18　eV.　The　most　detrimental　lesions　to　cell　survival　exhibit　the　highest　enhancements　by　factors　of　2-3.　Whereas　no　cluster　lesions　are　induced　by　electrons　of　energy　©　2020　American　Chemical　Society.