Time-staggered　administration　of　erlotinib　(Er)　and　doxorubicin　(DOX)　provides　significantly　enhanced　apoptosis　of　lung　cancer　cells,　but　this　administration　approach　has　not　been　translated　successfully　to　the　clinic　due　to　discrepant　formulation　parameters　and　different　routes　of　administration.　Here,　we　developed　a　MoS2-based　multifunctional　nanoplatform　capable　of　achieving　co-delivery　of　Er　and　DOX　and　controlled　drug　release　for　effective　cancer　therapy.　Er　was　first　connected　to　MoS2　nanosheets　via　click　chemistry　with　polyethylene　glycol　(PEG)　as　a　linker,　followed　by　incorporation　of　DOX.　The　resulting　MoS2-PEG-Er/DOX　converted　absorbed　near-infrared　(NIR)　light　into　heat,　which　achieved　the　controlled　release　of　DOX　and　induced　the　photothermal　ablation　of　cancer　cells.　After　cellular　uptake　of　MoS2-PEG-Er/DOX,　the　loaded　Er　directly　inhibited　epidermal　growth　factor　receptor　(EGFR)　signaling　cascade　to　suppress　cancer　cell　proliferation　and　promote　the　dynamic　rewiring　of　apoptotic　pathway,　which　sensitized　cancer　cells　to　the　action　of　the　NIR-triggered　released　DOX.　More　importantly,　MoS2-PEG-Er/DOX　upon　NIR　irradiation　achieved　the　synergetic　photothermal　chemotherapy　of　cancer,　which　effectively　inhibited　tumor　growth　in　lung　cancer　cell-bearing　mice.　The　results　of　this　study　demonstrate　the　excellent　antitumor　effect　of　MoS2-PEG-Er/DOX,　providing　a　promising　strategy　for　clinical　treatment　of　cancer.　©　2019　Elsevier　B.V.