Soft　tissue　engineering　has　been　seeking　ways　to　mimic　the　natural　extracellular　microenvironment　that　allows　cells　to　migrate　and　proliferate　to　regenerate　new　tissue.　Therefore,　the　reconstruction　of　soft　tissue　requires　a　scaffold　possessing　the　extracellular　matrix　(ECM)-mimicking　fibrous　structure　and　elastic　property,　which　affect　the　cell　functions　and　tissue　regeneration.　Herein,　an　effective　method　for　fabricating　nanofibrous　hydrogel　for　soft　tissue　engineering　is　demonstrated　using　gelatin–hydroxyphenylpropionic　acid　(Gel–HPA)　by　electrospinning　and　enzymatic　crosslinking.　Gel–HPA　fibrous　hydrogel　was　prepared　by　crosslinking　the　electrospun　fibers　in　ethanol-water　solution　with　an　optimized　concentration　of　horseradish　peroxidase　(HRP)　and　H2　O2　.　The　prepared　fibrous　hydrogel　held　the　soft　and　elastic　mechanical　property　of　hydrogels　and　the　three-dimensional　(3D)　fibrous　structure　of　electrospun　fibers.　It　was　proven　that　the　hydrogel　scaffolds　were　biocompatible,　improving　the　cellular　adhesion,　spreading,　and　proliferation.　Moreover,　the　fibrous　hydrogel　showed　rapid　biodegradability　and　promoted　angiogenesis　in　vivo.　Overall,　this　study　represents　a　novel　biomimetic　approach　to　generate　Gel–HPA　fibrous　hydrogel　scaffolds　which　have　excellent　potential　in　soft　tissue　regeneration　applications.　©　2020　by　the　authors.　Licensee　MDPI,　Basel,　Switzerland.