Access to chiral α-substituted-β-hydroxy arylphosphonates enabled by biocatalytic dynamic reductive kinetic resolution - Details

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Abstract：

Ketoreductase　(KRED)-catalyzed　dynamic　reductive　kinetic　resolution　(DYRKR)　of　α-substituted-β-keto　arylphosphonates　was　developed　as　a　generic　and　stereoselective　approach　to　synthesize　chiral　α-substituted-β-hydroxy　arylphosphonates,　with　moderate-to-excellent　isolated　yield　(up　to　96%),　good-to-excellent　diastereoselectivity　(up　to　＞99 : 99%　ee)　being　achieved.　This　journal　is　©　The　Royal　Society　of　Chemistry.

Keyword：

Chemistry Positive ions Stereoselectivity

Community：

[ 1 ] [Wang, Zexu]Department of Chemistry, Engineering Center of Catalysis and Synthesis for Chiral Molecules, Fudan University, Shanghai Engineering Research Center of Industrial Asymmetric Catalysis of Chiral Drugs, 220 Handan Road, Shanghai; 200433, China
[ 2 ] [Zeng, Yiping]FAFU-UCR Joint Center for Horticultural Biology and Metabolomics, Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, Fujian Agriculture and Forestry University, Fuzhou; 350002, China
[ 3 ] [Wu, Xiaofan]College of Chemical Engineering, Fuzhou University, 2 Xueyuan Road, Fuzhou; 350116, China
[ 4 ] [Li, Zihan]Department of Chemistry, Engineering Center of Catalysis and Synthesis for Chiral Molecules, Fudan University, Shanghai Engineering Research Center of Industrial Asymmetric Catalysis of Chiral Drugs, 220 Handan Road, Shanghai; 200433, China
[ 5 ] [Tao, Yuan]Department of Chemistry, Engineering Center of Catalysis and Synthesis for Chiral Molecules, Fudan University, Shanghai Engineering Research Center of Industrial Asymmetric Catalysis of Chiral Drugs, 220 Handan Road, Shanghai; 200433, China
[ 6 ] [Yu, Xiaomin]FAFU-UCR Joint Center for Horticultural Biology and Metabolomics, Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, Fujian Agriculture and Forestry University, Fuzhou; 350002, China
[ 7 ] [Huang, Zedu]Department of Chemistry, Engineering Center of Catalysis and Synthesis for Chiral Molecules, Fudan University, Shanghai Engineering Research Center of Industrial Asymmetric Catalysis of Chiral Drugs, 220 Handan Road, Shanghai; 200433, China
[ 8 ] [Chen, Fener]Department of Chemistry, Engineering Center of Catalysis and Synthesis for Chiral Molecules, Fudan University, Shanghai Engineering Research Center of Industrial Asymmetric Catalysis of Chiral Drugs, 220 Handan Road, Shanghai; 200433, China

Reprint 's Address：

[huang, zedu]department of chemistry, engineering center of catalysis and synthesis for chiral molecules, fudan university, shanghai engineering research center of industrial asymmetric catalysis of chiral drugs, 220 handan road, shanghai; 200433, china

Email：

huangzedu@fudan.edu.cn

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Source ：

Organic and Biomolecular Chemistry

ISSN： 1477-0520

Year： 2020

Issue： 14

Volume： 18

Page： 2672-2677

3 . 8 7 6

JCR@2020

2 . 9 0 0

JCR@2023

ESI HC Threshold：160

JCR Journal Grade：1

CAS Journal Grade：3

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WoS CC Cited Count：

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

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Chinese Cited Count：

30 Days PV： 0

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