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author：

Huang, Mengjiao (Huang, Mengjiao.) [1] | Yang, Juanjuan (Yang, Juanjuan.) [2] | Wang, Teng (Wang, Teng.) [3] | Song, Jia (Song, Jia.) [4] | Xia, Jinglu (Xia, Jinglu.) [5] | Wu, Lingling (Wu, Lingling.) [6] | Wang, Wei (Wang, Wei.) [7] | Wu, Qiaoyi (Wu, Qiaoyi.) [8] | Zhu, Zhi (Zhu, Zhi.) [9] | Song, Yanling (Song, Yanling.) [10] | Yang, Chaoyong (Yang, Chaoyong.) [11]

Indexed by：

EI

Abstract：

Immunotherapy　has　revolutionized　cancer　treatment,　but　its　efficacy　is　severely　hindered　by　the　lack　of　effective　predictors.　Herein,　we　developed　a　homogeneous,　low-volume,　efficient,　and　sensitive　exosomal　programmed　death-ligand　1　(PD-L1,　a　type　of　transmembrane　protein)　quantitation　method　for　cancer　diagnosis　and　immunotherapy　response　prediction　(HOLMES-ExoPD-L1).　The　method　combines　a　newly　evolved　aptamer　that　efficiently　binds　to　PD-L1　with　less　hindrance　by　antigen　glycosylation　than　antibody,　and　homogeneous　thermophoresis　with　a　rapid　binding　kinetic.　As　a　result,　HOLMES-ExoPD-L1　is　higher　in　sensitivity,　more　rapid　in　reaction　time,　and　easier　to　operate　than　existing　enzyme-linked　immunosorbent　assay　(ELISA)-based　methods.　As　a　consequence　of　an　outstanding　improvement　of　sensitivity,　the　level　of　circulating　exosomal　PD-L1　detected　by　HOLMES-ExoPD-L1　can　effectively　distinguish　cancer　patients　from　healthy　volunteers,　and　for　the　first　time　was　found　to　correlate　positively　with　the　metastasis　of　adenocarcinoma.　Overall,　HOLMES-ExoPD-L1　brings　a　fresh　approach　to　exosomal　PD-L1　quantitation,　offering　unprecedented　potential　for　early　cancer　diagnosis　and　immunotherapy　response　prediction.　©　2020　Wiley-VCH　Verlag　GmbH　&　Co.　KGaA,　Weinheim

Keyword：

Diagnosis Diseases Forecasting Thermophoresis

Community：

  • [ 1 ] [Huang, Mengjiao]The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, the Key Laboratory of Chemical Biology of Fujian Province, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen; 361005, China
  • [ 2 ] [Yang, Juanjuan]College of Biological Science and Engineering, Fuzhou University, Fuzhou; 350002, China
  • [ 3 ] [Wang, Teng]College of Biological Science and Engineering, Fuzhou University, Fuzhou; 350002, China
  • [ 4 ] [Song, Jia]Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai; 200127, China
  • [ 5 ] [Xia, Jinglu]College of Biological Science and Engineering, Fuzhou University, Fuzhou; 350002, China
  • [ 6 ] [Wu, Lingling]Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai; 200127, China
  • [ 7 ] [Wang, Wei]Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai; 200127, China
  • [ 8 ] [Wu, Qiaoyi]The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, the Key Laboratory of Chemical Biology of Fujian Province, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen; 361005, China
  • [ 9 ] [Zhu, Zhi]The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, the Key Laboratory of Chemical Biology of Fujian Province, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen; 361005, China
  • [ 10 ] [Song, Yanling]The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, the Key Laboratory of Chemical Biology of Fujian Province, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen; 361005, China
  • [ 11 ] [Song, Yanling]Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai; 200127, China
  • [ 12 ] [Yang, Chaoyong]The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, the Key Laboratory of Chemical Biology of Fujian Province, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen; 361005, China
  • [ 13 ] [Yang, Chaoyong]Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai; 200127, China

Reprint 's Address：

  • [song, yanling]the moe key laboratory of spectrochemical analysis & instrumentation, the key laboratory of chemical biology of fujian province, state key laboratory of physical chemistry of solid surfaces, department of chemical biology, college of chemistry and chemical engineering, xiamen university, xiamen; 361005, china;;[song, yanling]institute of molecular medicine, renji hospital, school of medicine, shanghai jiao tong university, shanghai; 200127, china

Email：


ylsong@xmu.edu.cn
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Source ：

Angewandte Chemie - International Edition

ISSN： 1433-7851

Year： 2020

Issue： 12

Volume： 59

Page： 4800-4805

1 5 . 3 3 6

JCR@2020

1 6 . 1 0 0

JCR@2023

ESI HC Threshold：160

JCR Journal Grade：1

CAS Journal Grade：2

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 175

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 4

Affiliated Colleges：

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