The　buffeting　response　of　a　structure　is　very　complex,　and　in　main　wind　resistant　design　codes/specifications　of　structures,　the　equivalent　static　wind　loads　(ESWL)　is　adopted　to　instead　the　real　dynamic　buffeting　analysis.　The　multi-target　ESWL　calculation　method　of　long-span　bridges　is　studied　from　a　new　perspective.　Firstly,　load　response　correlation　(LRC)　method　was　used　to　estimate　ESWL　vectors　at　the　nodes　of　girders　of　the　long-span　bridge　and　then　to　form　the　ESWL　matrix　FLRC.　Secondly,　the　proper　orthogonal　decomposition　(POD)　technique　was　applied　to　attaining　the　proper　orthogonal　matrix　φLRC　of　FLRC.　Thirdly,　with　the　buffeting　response　extreme　values　of　the　girder　regarded　as　the　equivalent　targets,　the　first　i-order　proper　modes　of　φLRC　were　used　as　the　base　vectors　to　reconstruct　ESWL,　so　that　the　multi-target　ESWL　can　be　obtained　in　least　square　meaning.　Finally,　East　Sea　cable-stayed　bridge　was　used　as　an　example　to　validate　the　effectiveness　of　the　method.　The　results　indicate　that　the　accuracy　of　buffeting　responses　calculated　by　multi-target　ESWL　and　the　rationality　of　ESWL　distribution　are　acceptable　by　using　the　proposed　method,　because　after　POD,　the　matrix　φLRC　contains　both　the　fluctuating　wind　pressure　information　and　the　buffeting　response　information,　which　are　ordered　according　to　the　significance.　©　2019,　Editorial　Office　of　China　Civil　Engineering　Journal.　All　right　reserved.