Poly(procaterol　hydrochloride)　(p-ProH)　polymeric　film　was　successfully　deposited　onto　the　carboxyl　multi-walled　carbon　nanotube　(CMWCNT)　modified　glass　carbon　electrode　(GCE)　to　construct　a　p-ProH/CMWCNT　composite　modified　GCE.　Due　to　the　synergistic　effect　of　p-ProH　and　CMWCNT　in　the　composite,　the　developed　sensor　can　enormously　enhance　the　oxidation　peak　current　of　bromhexine　hydrochloride　(BrH)　at　ca.　+　0.90　V.　Based　on　this　appearance,　an　electrochemical　method　was　established　for　the　sensitive　and　selective　determination　of　BrH　with　differential　pulse　voltammetry　(DPV).　Various　conditions　affecting　the　peak　current　response　of　BrH　were　studied　and　optimized.　Under　the　best　conditions,　the　oxidation　peak　current　of　BrH　is　linear　to　its　concentration　in　two　linear　dynamic　ranges　of　0.2-1.0　μmol　L-1　(R　=　0.9948)　and　1.0-8.0　μmol　L-1　(R　=　0.9956),　with　a　detection　limit　of　0.1　μmol　L-1　(S/N　=　3).　Interference　experiment　indicated　that　the　as-prepared　electrochemical　sensor　showed　wonderful　selectivity　to　the　recognition　of　BrH　and　was　free　from　disturbance　of　many　other　electro-active　substances　such　as　dopamine,　ascorbic　and　uric　acid.　Finally,　the　practicability　of　the　BrH　sensor　was　verified　by　the　satisfactory　results　acquired　from　the　BrH　determination　in　pharmaceutical　preparation　and　human　serum.　©　2019　The　Royal　Society　of　Chemistry.