In　this　study,　the　completely　autotrophic　nitrogen　removal　over　nitrite　(CANON)　process　was　started　successfully　in　a　pilot-scale　oxidation　ditch.　The　influent　ammonia　nitrogen　(NH4+-N)　concentration　was　about　40　mg/L,　while　the　effluent　NH4+-N　and　total　nitrogen　(TN)　concentrations　were　2.81　mg/L　and　7.80　mg/L,　respectively.　The　average　removal　efficiency　of　TN　was　82.17%.　After　the　employment　of　CANON　to　deal　with　actual　domestic　wastewater,　a　simultaneous　partial　nitrification,　anaerobic　ammonium　oxidation　(ANAMMOX),　and　denitrification　(SNAD)　process　was　gradually　started.　During　operation　of　the　reactor,　both　hydraulic　retention　time　(HRT)　and　aeration　/　non-aeration　time　were　important　parameters　for　the　biological　treatment　effect　and　effluent　quality　of　the　SNAD　process.　The　HRT　of　15　h,　and　an　aeration　/　non-aeration　time　of　3　h/1　h　was　recommended　as　the　optimal　operating　parameters　in　the　SNAD　process.　Sludge　activity　and　high-throughput　sequencing　analyses　showed　that　the　carriers　provided　a　suitable　environment　for　the　attachment　and　growth　of　anaerobic　ammonia-oxidizing　bacteria,　thus　ensuring　the　reaction　of　ANAMMOX.　This　study　can　provide　a　deeper　understanding　on　the　application　of　SNAD　treatment　of　domestic　wastewater　in　an　oxidation　ditch-type　continuous　flow　reactor.　©　2019　Elsevier　Ltd