The　synthesis　of　isobutanol　from　syngas　is　a　such　complicated　process,　and　the　relationship　between　catalyst　properties　and　isobutanol　formation　is　still　not　fully　understood　yet.　Coprecipitation　is　a　common　preparation　method　for　solid　composite　oxides　synthesis,　by　which,　the　catalyst　will　have　high　dispersion,　strong　interaction.　However,　it　also　remains　many　factors　affecting　the　preparation　process.　In　this　work,　the　effect　of　precipitation　temperature　on　the　properties　of　catalysts　at　the　beginning　of　precipitation　reaction　was　investigated,　and　the　relationship　between　the　properties　of　catalysts　and　the　formation　of　isobutanol　was　studied　by　different　characterization　methods　in　combination　with　the　catalysts　evaluation　results,　in　order　to　further　improve　the　formation　mechanism　of　isobutanol.　The　results　revealed　that　at　lower　precipitation　temperature　(30),　the　CuO　was　easier　to　be　reduced　due　to　the　better　Cu　dispersion　and　stronger　interaction　in　CuO　and　ZrO2,　at　the　same　time　as　the　CuO　and　ZrO2　could　form　better　solid　solutions　at　this　condition.　Meanwhile,　hydroxyl　groups　were　formed　on　the　catalyst　surface　at　lower　precipitation　temperature　during　the　catalyst　preparation　process,　therefore　these　hydroxyl　groups　could　react　with　CO　to　form　surface　C1　species,　which　further　promoted　the　growth　of　carbon　chain　and　improved　the　selectivity　of　isobutanol.　With　the　increase　of　precipitation　temperature,　CuO　particles　were　enlarged;　CuO-ZrO2　solid　solution　was　gradually　destroyed;　the　interaction　in　CuO　and　ZrO2　was　weakened;　and　the　content　of　surface　hydroxyl　was　decreased,　resulting　in　a　decrease　of　surface　C1　species　and　isobutanol　selectivity.　Among　all　the　catalysts,　the　highest　selectivity　of　isobutanol　(38.7%)　was　obtained　over　the　CLZ-30　catalyst.　©　2019,　Science　Press.　All　right　reserved.