Synthesis　of　multifunctional　fabrics　with　long-lasting　durability　remains　a　quest　for　researchers　in　the　past　decade.　In　this　work,　robust　coatings　on　cotton　fabrics　for　superhydrophobic,　antibacterial,　and　UV-blocking　functionalities　by　a　dual-stage　silanization　technique　are　reported.　Aminopropyltriethoxysilane　is　utilized　as　a　silane　cross-linker　to　anchor　zinc　oxide　nanoparticles　to　the　pristine　cotton　fabric　surface,　followed　by　modification　with　a　silane　hydrophobe,　hexadecyltrimethoxysilane.　This　dual-silanization　approach　results　in　highly　functional　fabrics　displaying　superhydrophobicity　with　a　water　contact　angle　of　154°,　water　shedding　angle　of　2°,　antibacterial　activity　of　up　to　98%,　and　UV-blocking　ability　more　than　200　times　of　pristine　cotton.　The　as-prepared　fabrics　display　excellent　durability　against　abrasion,　ultrasonic　washing,　immersion　in　different　pH　solutions,　and　UV　irradiation.　Moreover,　the　air　permeability　and　flexural　rigidity　of　the　fabrics　are　still　within　the　required　breathability　and　wearer　comfortability　for　clothing　applications.　The　reported　process　is　simple,　cost-effective,　and　green,　showing　great　promise　for　large-scale　production　of　multifunctional　fabrics.　©　2019　WILEY-VCH　Verlag　GmbH　&　Co.　KGaA,　Weinheim