Earthquake-induced　building　collapse　and　progressive　collapse　due　to　accidental　local　failure　of　vertical　components　are　the　two　most　common　failure　modes　of　reinforced　concrete　(RC)　frame　structures.　Conventional　design　methods　usually　focus　on　the　design　requirements　of　a　specific　hazard　but　neglect　the　interactions　between　different　designs.　For　example,　the　progressive　collapse　design　of　an　RC　frame　often　yields　increased　reinforcement　and　flexural　strength　of　the　beams.　As　a　result,　the　seismic　design　principle　of　＇strong-column-weak-beam＇　may　be　violated,　which　may　lead　to　unfavorable　failure　modes　and　weaken　the　seismic　performance.　To　avoid　these　adverse　effects　of　the　progressive　collapse　design　on　the　seismic　resistance　of　RC　frames,　a　novel　structural　detailing　is　proposed　in　this　study.　The　proposed　detailing　technique　intends　to　concurrently　improve　the　seismic　and　progressive　collapse　performances　of　an　RC　frame　by　changing　the　layout　of　the　newly　added　longitudinal　reinforcement　against　progressive　collapse　without　introducing　any　additional　reinforcement.　A　six-story　RC　frame　is　used　as　the　prototype　building　for　this　investigation.　Both　cyclic　and　progressive　collapse　tests　are　conducted　to　validate　the　performance　of　the　proposed　structural　detailing.　Based　on　the　experimental　results,　detailed　finite　element　(FE)　models　of　the　RC　frame　with　different　reinforcement　layouts　are　established.　The　seismic　and　progressive　collapse　resistances　of　different　models　are　compared　based　on　the　incremental　dynamic　analysis　(IDA)　and　nonlinear　dynamic　alternate　path　(AP)　methods,　respectively.　The　results　indicate　that　the　proposed　structural　detailing　can　effectively　resolve　the　conflict　between　the　seismic　and　progressive　collapse　designs.　©　2019　John　Wiley　&　Sons,　Ltd.