Nuclear　receptors　are　transcriptional　regulators　involved　in　almost　all　biological　processes　such　as　cell　growth,　differentiation,　apoptosis,　substance　metabolism　and　tumor　formation,　and　they　can　be　regulated　by　small　molecules　that　bind　to　them.　Autophagy　is　a　special　way　of　programmed　cell　death　and　it　is　a　highly　conserved　metabolic　process.　Once　autophagy　defects　or　excessive　autophagy　occur,　the　disease　will　develop.　In　recent　years,　numerous　studies　have　shown　that　nuclear　receptors　are　related　to　autophagy.　Therefore,　this　paper　mainly　reviews　the　research　progress　on　nuclear　receptors　involved　in　the　regulation　of　autophagy,　and　focuses　on　the　mechanism　of　several　nuclear　receptors　involved　in　the　regulation　of　autophagy,　aiming　at　understanding　the　molecular　basis　of　how　nuclear　receptors　participate　in　regulating　autophagy,　as　well　as　providing　possible　ideas　and　strategies　for　the　treatment　of　corresponding　diseases.　Copyright　©　2018　by　Editorial　Office　of　Journal　of　Biomedical　Engineering.