Objective:　This　essay　was　to　study　the　transglutaminase　catalyzed　cross-linking　of　chicken　and　kidney　bean　protein,　encapsulating　curcumin　using　the　hybrid　protein　as　the　wall　material,　conditions　of　TGase,　different　protein　ratio　and　the　wall　/　core　ratio　were　studied　for　the　effect　on　encapsulation　rate.　Methods:　Two　phase　method　was　used　to　prepared　hybrid　protein-curcumin　microspheres,　doing　single　factor　test　and　orthogonal　experiment　to　research　effect　of　conditions　of　TGase　on　encapsulation　rate.　Observing　the　effect　of　hybrid　protein　encapsulated　curcumin　by　using　environmental　scanning　electron　microscope.　Result:　The　effect　of　conditions　of　TGase　on　encapsulation　rate　was　extremely　significant.　The　optimal　level　of　each　factor　is　time　6　h,　temperature　45　,　the　amount　of　TGase　80　:　1(protein　:　TGase).　Different　protein　ratio　and　the　wall　/　core　ratio　had　some　effect　on　encapsulation　rate.　Because　of　the　large　particles　of　curcumin,　hybrid　protein　had　more　wrapped　effect　on　curcumin.　Conclusion:　Conditions　of　TGase,　different　protein　ratio　and　wall　/　core　ratio　had　effect　on　encapsulation　rate.　Hybrid　protein　had　more　wrapped　effect　on　curcumin.　©　2018,　Editorial　Office　of　Journal　of　CIFST.　All　right　reserved.