The　Responsive　Web　Design　(RWD)　aims　at　crafting　sites　to　provide　an　optimal　viewing　experience　in　easy　reading　and　navigation　with　a　minimum　of　resizing,　panning,　and　scrolling　across　a　wide　range　of　devices　such　as　from　desktop　computer　monitors　to　mobile　phones.　And　the　modern-day　healthcare　needs　and　delivery　is　complex,　and　the　use　of　Information　and　Communications　Technologies　(ICT)　has　made　some　positive　impact　in　attending　to　such　needs　that　e-health　applications　require.　This　paper　deals　with　E-health　web　application　framework,　cloud　platform　and　responsive　web　design,　which　aim　to　adjust　the　presentation　on　mobile　devices.　This　work　presents　the　whole　development　process　of　the　self-care　management　web-app　framework,　which　provides　instructive　supports　for　future　other　E-health　field　application.　A　prototype　is　developed　by　using.　Net,　CSS3,　Java　script　and　HTML5　technologies.　The　system　test　and　evaluation　is　made　to　show　the　system’s　usability.　©　2018　Taiwan　Academic　Network　Management　Committee.　All　rights　reserved.