The　solid　acid　SO42　−/TiO2　was　prepared　by　immersion　method　and　applied　for　synthesis　of　propylene　glycol　methyl　ether　acetate　(PMA)　through　esterification　reaction　of　propylene　glycol　monomethyl　ether　(PM)　and　acetic　acid　(HAc).　The　optimal　catalyst　preparation　condition　was　determined　by　orthogonal　analysis　of　parameters　in　a　five-factor　and　four-level　test.　The　obtained　solid　acid　catalysts　were　characterized　in　detail　by　means　of　X-ray　powder　diffraction,　thermogravimetry,　pyridine　adsorbed　IR　analysis,　scanning　electron　microscopy,　and　BET　surface　area　method.　Synthesis　of　PMA　was　studied　in　this　paper　through　experimental　investigation　of　reaction　conditions　such　as　temperature,　molar　ratio　of　reactants,　catalyst　dosage　and　agitation　speed.　Based　on　its　possible　reaction　mechanism,　a　pseudo-homogeneous　kinetic　model　was　established　and　its　activation　energies　Ea+　and　Ea−　65.68　×　103　J·mol−　1　and　57.78　×　103　J·mol−　1,　were　estimated.　To　prepare　shaped　solid　acid　catalyst　SO42　−/TiO2,　the　shaping　method　of　impregnation–shaping–impregnation　was　applied.　The　optimal　molding　formulation　of　solid　acid　catalyst,　obtained　from　the　orthogonal　test,　was　found　to　be　binder　7　wt.%,　reinforcing　agent　20　wt.%,　pore　forming　material　2.5　wt.%,　and　lubricant　4　wt.%.　The　results　of　performance　test　of　catalyst　demonstrated　that　the　shaped　solid　acid　catalyst　exhibited　high　activity　and　stability.　©　2016