This　paper　aims　to　present　the　feasibility　of　conducting　the　transesterification　of　propylene　glycol　ether　(PM)　with　methyl　acetate　(MeAc)　in　a　reactive　distillation　(RD)　column　to　improve　the　reaction　conversion.　The　essential　thermodynamic　and　reaction　kinetic　data　of　the　reaction　system　were　measured　for　the　feasibility　study.　There　is　only　one　azeotrope,　MeAc-MeOH,　in　the　reaction　system,　and　the　NRTL　model　could　describe　well　the　thermodynamic　behavior　of　this　system.　The　transesterification　of　PM　with　MeAc　is　an　endothermic　reaction　with　activation　energy　E　=　55.704　kJ·mol-1.　The　feasibility　was　analyzed　by　residue　curve　maps　(RCM),　showing　that　full　conversion　of　PM　could　be　realized　by　RD　with　a　mole　ratio　of　MeAc-PM　larger　than　2.882.　The　intensification　effect　was　experimentally　verified　in　a　batch　RD　column.　Finally,　some　important　parameters　are　given　through　the　conceptual　design　to　develop　a　continuous　RD　column　for　the　transesterification　of　PM　with　MeAc.　©　2017　American　Chemical　Society.