To　study　the　isolation　performance　of　composite　base-isolated　structures　under　different　support　layouts,　numerical　simulation　and　shaking　table　test　were　carried　out　on　the　two　kinds　of　isolation　layer　arrangement,　in　which　the　elastic　sliding　bearings　(ESB)　was　respectively　arranged　at　the　different　positions　of　the　big　and　small　axial　force.　This　was　to　explore　the　absolute　acceleration　and　displacement　response　of　the　story.　The　four　scaled-models　of　the　prototype,　which　was　a　large　chassis　isolation　structure　with　single　tower　characterized　by　vast　difference　in　column　axial　force,　were　designed　and　produced.　These　were　the　composite　base　isolation　model　1　(ESB　was　located　at　the　position　of　the　big　axial　force,　which　was　referred　as　composite　base　isolation　1),　the　composite　base　isolation　model　2　(ESB　was　located　at　the　position　of　the　small　axial　force,　which　was　referred　as　composite　base　isolation　2),　the　contrasting　pure　base　isolation　model　(isolation　rubber　bearings　were　adopted,　which　was　referred　as　pure　base　isolation)　and　the　seismic　model.　The　results　show　that　the　natural　vibration　period　of　composite　base　isolation　1　is　obviously　larger　than　that　of　composite　base　isolation　2　and　pure　base　isolation.　The　acceleration　and　displacement　response　reduction-rate　of　the　three　kinds　of　isolation　model　structures　are　above　71.94%　and　75.91%　respectively.　The　response　of　composite　base　isolation　1　and　2　is　close　to　and　better　than　that　of　pure　base　septum.　With　the　increase　of　acceleration　peak　of　ground　motion,　the　damping　effect　of　large　chassis　floor　of　composite　base　isolation　1　is　better　than　that　of　composite　base　isolation　2,　but　the　damping　effect　of　the　upper　tower　floor　is　close.　The　results　also　indicate　that　the　composite　base　isolation　structure　should　place　the　ESB　in　a　position　of　big　axial　force　when　the　column　axial　force　is　vast　difference.　©　2017,　The　Editorial　Board　of　Journal　of　Basic　Science　and　Engineering.　All　right　reserved.