This　paper　presents　an　original　Hexacopter　with　three　nonplanar　rotor　pairs　where　the　variable　thrust　is　provided　by　fixed-pitch　rotors　with　variable　speed.　The　corresponding　face-to-face　rotor　pair　(F-F)　and　back-to-back　rotor　pair　(B-B)　are　proposed　as　the　research　components　to　maximize　the　overall　aerodynamic　performance　with　different　transverse　spacings　and　disk　plane　angles.　Together　with　the　rotor　interactions　involved　in　low　Reynolds　number　(Re)　environments,　experiments　in　the　presence　of　the　uncertainty　analysis　are　performed　to　validate　the　aerodynamic　interference　and　test　the　effectiveness　of　the　proposed　rotor　pairs.　Experimental　results　show　that　the　performance　of　the　rotor　pair　can　be　improved　significantly　by　having　an　optimal　combination　with　a　larger　angle　and　a　moderate　spacing.　Indeed,　the　aerodynamic　interactions　between　the　two　rotors　decrease　with　a　larger　disk　plane　angle,　and　the　aerodynamic　interference　of　the　rotor　pairs　is　mainly　involved　in　the　face　to　face　type.　Furthermore,　parametric　studies　were　also　performed　to　study　the　effects　of　low　Re　and　to　attempt　to　maximize　the　thrust　and　minimize　the　total　power　required　in　hover　flight.　Useful　conclusions　are　provided　for　the　further　aerodynamic　analysis　and　control　strategy　to　meet　design　requirements.　©　2017　by　ASME.