Development　of　novel　van　der　Waals　(vdW)　heterostructures　from　various　two-dimensional　(2D)　materials　shows　unprecedented　possibilities　by　combining　the　advantageous　properties　of　their　building　layers.　In　particular,　transforming　the　vdW　heterostructures　from　type-I　to　type-II　is　of　great　interest　and　importance　to　achieve　efficient　charge　separation　in　photocatalytic,　photovoltaic,　and　optoelectronic　devices.　In　this　work,　by　means　of　ab　initio　calculations,　we　have　systematically　investigated　the　electronic　structures,　optical　properties,　and　mechanical　properties　of　MXene/Blue　Phosphorene　(BlueP)　vdW　heterostructures　under　various　deformations.　We　highlight　that,　under　strain,　the　type-I　heterostructures　can　be　transformed　to　type-II　with　their　conduction　band　minimum　(CBM)　and　valence　band　maximum　(VBM)　separated　in　different　layers.　Interestingly,　the　locations　of　the　CBM　or　VBM　in　MXene/BlueP　vdW　heterostructures　can　also　be　reversed　by　compressive　or　tensile　strain　between　the　building　layers,　which　indicates　that　either　layer　can　be　utilized　as　an　electron　donor　or　acceptor　by　varying　its　deformation　conditions.　Meanwhile,　this　compressive　(tensile)　strain　can　also　induce　a　red　(blue)　shift　in　the　optical　absorption　spectra　of　MXene/BlueP　vdW　heterostructures.　Finally,　our　results　on　the　mechanical　flexibility　and　deformation　mechanism　of　MXene/BlueP　vdW　heterostructures　suggest　their　great　long-term　stability　as　well　as　promising　applications　in　flexible　devices.　We　believe　that　our　findings　will　open　a　new　way　for　the　modulation　and　development　of　vdW　heterostructures　in　flexible　optical/electronic　devices.　©　The　Royal　Society　of　Chemistry.