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author:

Yang, Jie (Yang, Jie.) [1] | Lin, Yonghui (Lin, Yonghui.) [2] | Yang, Xiaodan (Yang, Xiaodan.) [3] | Ng, Tzi Bun (Ng, Tzi Bun.) [4] | Ye, Xiuyun (Ye, Xiuyun.) [5] | Lin, Juan (Lin, Juan.) [6]

Indexed by:

EI

Abstract:

Magnetic cross-linked enzyme aggregates (M-CLEAs) were prepared for Cerrena laccase and used in antibiotic treatment. Of the seven antibiotics examined in this study, Cerrena laccase M-CLEAs were most effective in degradation of tetracycline (TC) and oxytetracycline (OTC), followed by ampicillin, sulfamethoxazole and erythromycin. The redox mediator ABTS was not able to improve efficiencies of degradation of TC and OTC. Cerrena laccase at 40 U/mL eliminated 100 μg/mL TC at pH 6 and 25 °C in 48 h in the absence of a redox mediator, with over 80% degradation occurring within the first 12 h. Laccase treatment also significantly suppressed the antimicrobial activity of TC and OTC. Three TC transformation products, the levels of which initially increased and subsequently decreased during laccase treatment were identified by using LC-TOF MS. A mechanism of laccase-mediated TC oxidation was proposed based on the identified intermediates. © 2016 Elsevier B.V.

Keyword:

Antibiotics Enzymes Microorganisms Reaction intermediates

Community:

  • [ 1 ] [Yang, Jie]Fujian Key Laboratory of Marine Enzyme Engineering, Fuzhou University, Fujian; 350116, China
  • [ 2 ] [Lin, Yonghui]Technical Center, Fujian Entry-Exit Inspection and Quarantine Bureau, Fuzhou; Fujian; 350001, China
  • [ 3 ] [Yang, Xiaodan]Fujian Key Laboratory of Marine Enzyme Engineering, Fuzhou University, Fujian; 350116, China
  • [ 4 ] [Ng, Tzi Bun]School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, Hong Kong
  • [ 5 ] [Ye, Xiuyun]Fujian Key Laboratory of Marine Enzyme Engineering, Fuzhou University, Fujian; 350116, China
  • [ 6 ] [Lin, Juan]Fujian Key Laboratory of Marine Enzyme Engineering, Fuzhou University, Fujian; 350116, China

Reprint 's Address:

  • [yang, jie]fujian key laboratory of marine enzyme engineering, fuzhou university, fujian; 350116, china

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Source :

Journal of Hazardous Materials

ISSN: 0304-3894

Year: 2017

Volume: 322

Page: 525-531

6 . 4 3 4

JCR@2017

1 2 . 2 0 0

JCR@2023

ESI HC Threshold:177

JCR Journal Grade:1

CAS Journal Grade:1

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count: 192

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 3

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