As　one　of　the　stimulators　on　bone　formation,　osteogenic　growth　peptide　(OGP)　improves　both　proliferation　and　differentiation　of　the　bone　cells　in　vitro　and　in　vivo.　The　aim　of　this　work　was　the　preparation　of　three　dimensional　porous　poly(Ε-caprolactone)　(PCL)　scaffold　with　high　porosity,　well　interpore　connectivity,　and　then　its　surface　was　modified　by　using　chitosan　(CS)/OGP　coating　for　application　in　bone　regeneration.　In　present　study,　the　properties　of　porous　PCL　and　CS/OGP　coated　PCL　scaffold,　including　the　microstructure,　water　absorption,　porosity,　hydrophilicity,　mechanical　properties,　and　biocompatibility　in　vitro　were　investigated.　Results　showed　that　the　PCL　and　CS/OGP-PCL　scaffold　with　an　interconnected　network　structure　have　a　porosity　of　more　than　91.5,　80.8%,　respectively.　The　CS/OGP-PCL　scaffold　exhibited　better　hydrophilicity　and　mechanical　properties　than　that　of　uncoated　PCL　scaffold.　Moreover,　the　results　of　cell　culture　test　showed　that　CS/OGP　coating　could　stimulate　the　proliferation　and　growth　of　osteoblast　cells　on　CS/OGP-PCL　scaffold.　These　finding　suggested　that　the　surface　modification　could　be　a　effective　method　on　enhancing　cell　adhesion　to　synthetic　polymer-based　scaffolds　in　tissue　engineering　application　and　the　developed　porous　CS/OGP-PCL　scaffold　should　be　considered　as　alternative　biomaterials　for　bone　regeneration.　©　2017　Informa　UK　Limited,　trading　as　Taylor　&　Francis　Group.