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author:

Cui, Zhixiang (Cui, Zhixiang.) [1] | Lin, Luyin (Lin, Luyin.) [2] | Si, Junhui (Si, Junhui.) [3] | Luo, Yufei (Luo, Yufei.) [4] | Wang, Qianting (Wang, Qianting.) [5] | Lin, Yongnan (Lin, Yongnan.) [6] | Wang, Xiaofeng (Wang, Xiaofeng.) [7] | Chen, Wenzhe (Chen, Wenzhe.) [8]

Indexed by:

EI

Abstract:

As one of the stimulators on bone formation, osteogenic growth peptide (OGP) improves both proliferation and differentiation of the bone cells in vitro and in vivo. The aim of this work was the preparation of three dimensional porous poly(Ε-caprolactone) (PCL) scaffold with high porosity, well interpore connectivity, and then its surface was modified by using chitosan (CS)/OGP coating for application in bone regeneration. In present study, the properties of porous PCL and CS/OGP coated PCL scaffold, including the microstructure, water absorption, porosity, hydrophilicity, mechanical properties, and biocompatibility in vitro were investigated. Results showed that the PCL and CS/OGP-PCL scaffold with an interconnected network structure have a porosity of more than 91.5, 80.8%, respectively. The CS/OGP-PCL scaffold exhibited better hydrophilicity and mechanical properties than that of uncoated PCL scaffold. Moreover, the results of cell culture test showed that CS/OGP coating could stimulate the proliferation and growth of osteoblast cells on CS/OGP-PCL scaffold. These finding suggested that the surface modification could be a effective method on enhancing cell adhesion to synthetic polymer-based scaffolds in tissue engineering application and the developed porous CS/OGP-PCL scaffold should be considered as alternative biomaterials for bone regeneration. © 2017 Informa UK Limited, trading as Taylor & Francis Group.

Keyword:

Biocompatibility Biomechanics Bone Cell adhesion Cell culture Cell engineering Cells Chitosan Coatings Hydrophilicity Mechanical properties Peptides Porosity Scaffolds (biology) Tissue Tissue regeneration Water absorption

Community:

  • [ 1 ] [Cui, Zhixiang]School of Materials Science and Engineering, Fujian University of Technology, Fuzhou, China
  • [ 2 ] [Cui, Zhixiang]Fujian Provincial Key Laboratory of Advanced Materials Processing and Application, Fuzhou, China
  • [ 3 ] [Cui, Zhixiang]School of Materials Science and Engineering, Fuzhou University, Fuzhou, China
  • [ 4 ] [Cui, Zhixiang]National Center for International Research of Micro-nano Molding Technology & Key Laboratory for Micro Molding Technology of Henan Province, Zhengzhou University, Zhengzhou, China
  • [ 5 ] [Lin, Luyin]School of Materials Science and Engineering, Fujian University of Technology, Fuzhou, China
  • [ 6 ] [Lin, Luyin]Fujian Provincial Key Laboratory of Advanced Materials Processing and Application, Fuzhou, China
  • [ 7 ] [Si, Junhui]School of Materials Science and Engineering, Fujian University of Technology, Fuzhou, China
  • [ 8 ] [Si, Junhui]Fujian Provincial Key Laboratory of Advanced Materials Processing and Application, Fuzhou, China
  • [ 9 ] [Luo, Yufei]School of Pharmacy, Fujian Medical University, Fuzhou, China
  • [ 10 ] [Wang, Qianting]School of Materials Science and Engineering, Fujian University of Technology, Fuzhou, China
  • [ 11 ] [Wang, Qianting]Fujian Provincial Key Laboratory of Advanced Materials Processing and Application, Fuzhou, China
  • [ 12 ] [Lin, Yongnan]School of Materials Science and Engineering, Fujian University of Technology, Fuzhou, China
  • [ 13 ] [Lin, Yongnan]Fujian Provincial Key Laboratory of Advanced Materials Processing and Application, Fuzhou, China
  • [ 14 ] [Wang, Xiaofeng]National Center for International Research of Micro-nano Molding Technology & Key Laboratory for Micro Molding Technology of Henan Province, Zhengzhou University, Zhengzhou, China
  • [ 15 ] [Chen, Wenzhe]School of Materials Science and Engineering, Fujian University of Technology, Fuzhou, China
  • [ 16 ] [Chen, Wenzhe]Fujian Provincial Key Laboratory of Advanced Materials Processing and Application, Fuzhou, China
  • [ 17 ] [Chen, Wenzhe]School of Materials Science and Engineering, Fuzhou University, Fuzhou, China

Reprint 's Address:

  • [cui, zhixiang]fujian provincial key laboratory of advanced materials processing and application, fuzhou, china;;[cui, zhixiang]national center for international research of micro-nano molding technology & key laboratory for micro molding technology of henan province, zhengzhou university, zhengzhou, china;;[cui, zhixiang]school of materials science and engineering, fuzhou university, fuzhou, china;;[cui, zhixiang]school of materials science and engineering, fujian university of technology, fuzhou, china

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Source :

Journal of Biomaterials Science, Polymer Edition

ISSN: 0920-5063

Year: 2017

Issue: 9

Volume: 28

Page: 826-845

1 . 9 1 1

JCR@2017

3 . 6 0 0

JCR@2023

ESI HC Threshold:306

JCR Journal Grade:2

CAS Journal Grade:3

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count: 19

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 5

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