A　renewable,　amphoteric　functionalized　mesoporous　silica　(AG-SBA-15)　was　synthesized　with　a　two-steps　process:　firstly,　aluminum　atoms　was　incorporated　into　the　framework　of　SBA-15　and　then　melamine-based　dendrimers　groups　were　anchored　onto　the　Al-substituted　SBA-15.　The　amphoteric　AG-SBA-15　kept　an　ordered　hexagonal　mesostructure　after　the　functionalization　and　regeneration　processes　and　exhibited　an　excellent　performance　for　simultaneous　removal　of　Cu(II)　cations　and　Cr2O72-　metalloid　anions　from　aqueous　solution,　with　the　maximum　adsorption　capacity　of　2.216mmol/g　Cu(II)　and　3.305mmol/g　Cr2O72-,　respectively.　Batch　adsorption　experiments　results　indicated　that　the　optimized　pH　value　for　simultaneous　removal　of　Cu(II)　and　Cr2O72-　was　5.0.　The　adsorption　rate　was　extremely　fast　and　the　equilibrium　reached　within　30min.　The　adsorption　of　Cu(II)　and　Cr2O72-　by　AG-SBA-15　were　fitted　better　to　Langmuir　than　Freundlich　Model　and　thermodynamic　parameters　revealed　the　spontaneous　and　exothermic　nature　of　the　adsorption.　Reusability　studies　of　AG-SBA-15　were　carried　out　by　5　repeated　adsorption-desorption　cycles　and　the　results　confirmed　that　AG-SBA-15　could　be　easily　reused　with　little　loss　in　removal　efficiency.　Furthermore,　simultaneous　removal　mechanism　of　Cu(II)　and　Cr2O72-　by　AG-SBA-15　was　proposed　by　X-ray　photoelectron　spectroscope　analysis　(XPS),　which　revealed　that　Cu(II)　was　adsorbed　by　a　combination　of　electrostatic　interaction,　while　Cr(VI)　could　be　immobilized　by　reduction.　©　2015　Elsevier　B.V.