Amplified electrochemical sensing of lead ion based on DNA-mediated self-assembly-catalyzed polymerization - Details

author：

Zhang, Bing (Zhang, Bing.) ^[1] | Chen, Jinfeng (Chen, Jinfeng.) ^[2] | Liu, Bingqian (Liu, Bingqian.) ^[3] | Tang, Dianping (Tang, Dianping.) ^[4]

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Abstract：

Lead　ion　(Pb2+,　a　heavy　metal　ion　existed　every　aspect　of　life)　is　one　of　the　most　important　hazards　for　environment　and　human　health.　Herein　we　design　an　in-situ　amplified　electronic　monitoring　system　for　sensitive　determination　of　Pb2+　on　Pb2+-specific　DNAzyme-modified　sensing　interface.　The　assay　consists　of　target-triggered　cleavage　of　Pb2+-specific　DNAzyme,　initiator　strand-induced　DNA　hybridization　chain　reaction,　formation　of　hemin/G-quadruplex　-based　DNAzyme　and　its　automatically　catalyzed　polymerization　of　aniline　monomer　along　the　double-stranded　DNA.　Experimental　results　indicated　that　the　catalytic　currents　of　the　as-produced　polyaniline　were　linearly　dependent　on　target　Pb2+　concentrations　from　0.05　to　50nM　with　a　detection　limit　(LOD)　of　32pM.　Such　a　synergistic　effect　of　hybridization　chain　reaction　with　DNAzyme-catalyzed　polymerization　provided　a　universal　platform　for　sensitive　screening　of　target　Pb2+,　thereby　holding　great　promise　for　application　in　practice.　©　2015　Elsevier　B.V.

Keyword：

Aniline Catalysis DNA Health hazards Heavy metals Metal ions Polyaniline Polymerization Self assembly

Community：

[ 1 ] [Zhang, Bing]Key Laboratory of Analysis and Detection for Food Safety (MOE Fujian Province), Institute of Nanomedicine and Nanobiosensing, Department of Chemistry, Fuzhou University, Fuzhou; 350108, China
[ 2 ] [Chen, Jinfeng]Key Laboratory of Analysis and Detection for Food Safety (MOE Fujian Province), Institute of Nanomedicine and Nanobiosensing, Department of Chemistry, Fuzhou University, Fuzhou; 350108, China
[ 3 ] [Liu, Bingqian]Key Laboratory of Analysis and Detection for Food Safety (MOE Fujian Province), Institute of Nanomedicine and Nanobiosensing, Department of Chemistry, Fuzhou University, Fuzhou; 350108, China
[ 4 ] [Tang, Dianping]Key Laboratory of Analysis and Detection for Food Safety (MOE Fujian Province), Institute of Nanomedicine and Nanobiosensing, Department of Chemistry, Fuzhou University, Fuzhou; 350108, China

Reprint 's Address：

[tang, dianping]key laboratory of analysis and detection for food safety (moe fujian province), institute of nanomedicine and nanobiosensing, department of chemistry, fuzhou university, fuzhou; 350108, china

Email：

dianping.tang@fzu.edu.cn

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Source ：

Biosensors and Bioelectronics

ISSN： 0956-5663

Year： 2015

Volume： 69

Page： 230-234

7 . 4 7 6

JCR@2015

1 0 . 7 0 0

JCR@2023

ESI HC Threshold：265

JCR Journal Grade：1

Cited Count：

WoS CC Cited Count： 0

SCOPUS Cited Count： 36

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 1

Affiliated Colleges：

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